PROTEOMIC TEST FOR ANTI-PD-1 CHECKPOINT BLOCKADE TREATMENT OF METASTATIC MELANOMA WITH AND WITHOUT BRAF MUTATIONS

Proteomic test for anti-PD-1 checkpoint blockade treatment of metastatic melanoma with and without BRAF mutations

Abstract The therapeutic landscape in metastatic melanoma has changed dramatically in the last decade, with the success of immune checkpoint inhibitors resulting in durable responses for a large number of patients.For patients with BRAF mutations, combinations of BRAF and MEK inhibitors demonstrated response rates and benefit comparable to those fr

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Accidents features in construction

This work aims to highlight the problem of accidents in the construction industry.On the basis of collected and processed information the accidents classification in the building is presented, depending on the building erection stage.The article gives a detailed description and analysis of such cases in the Table Lamp Youth construction.The collect

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Sensitivities of surface wave velocities to the medium parameters in a radially anisotropic spherical Earth and inversion strategies

Sensitivity kernels or partial derivatives of phase velocity (c) and group velocity (U) with respect to medium parameters are useful to interpret a given set of observed surface wave velocity data.In addition to phase velocities, group velocities are also being observed to find the radial anisotropy of the crust and mantle.However, sensitivities of

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